PICO is a common mnemonic in Health Care research to help researchers form a clinically answerable question:
P - Patient, population or "problem"
I - Intervention
C - Comparison (if no comparison, C can stand for "control"
O - Outcome
You will sometimes see variations on this:
Adapted from: Melnyk, B. M., & Fineout-Overholt, E. (2011). Evidence-based practice in nursing & healthcare: A guide to best practice. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins.